Misner has guest starred on many TV series, including three of the series in the Law & Order franchise—Law & Order: Criminal Intent (2001/2005), Law & Order: Special Victims Unit (2002) and Law & Order (2006)—as well as both CSI: Crime Scene Investigation (2002) and CSI: Miami (2004). She appeared as Theresa on Rescue Me (2006–07), and later as Gretchen Martin in the 2007 miniseries The Bronx Is Burning. She appeared in two episodes of the hit CBS procedural Without a Trace during the 2004–2005 television season. In several episodes of the first season (2011) in Person of Interest, Misner plays opposite Jim Caviezel as his ex-girlfriend Jessica in flashbacks. In 2017, Misner had a guest appearance as Philomena on The Blacklist.